Certain dietary nutrients may play a critical role in reducing asthma risks caused by indoor air pollutants. Using data from the Comparative Toxicogenomics Database (CTD), researchers uncovered key nutrients that interact with molecular pathways linked to asthma, including gamma-tocopherol, vitamin A, resveratrol, theophylline and zinc.
The study, “The Protective Role of Dietary Nutrients in Mitigating Asthma Risks Induced By Indoor Air Pollutants: A Comparative Toxicogenomics Perspective,” was published in Scientific Reports.
The analysis examined nearly 1,200 curated chemical-gene-phenotype-disease interaction modules, identifying 60 key genes and 236 phenotypes associated with oxidative stress, inflammation and immune regulation. Resveratrol emerged as a standout, influencing the expression of 51 genes and modulating 187 phenotypes. This suggests its strong potential in reducing pro-inflammatory cytokine production and oxidative damage.
The study also highlighted the role of these nutrients in regulating critical mediators, such as IL6 and TNF, which are central to managing acute inflammation and preventing chronic airway remodeling. Researchers said their findings provide molecular evidence that nutritional interventions could serve as a complementary strategy to traditional asthma management.
Although the research underscores the promise of diet-based approaches, the study’s authors called for further in vitro and in vivo studies to explore additional nutrients like flavonoids, vitamin C and vitamin D. Researchers said the study sets the stage for future clinical trials and nutraceutical therapies aimed at improving global respiratory health.
